Grapevine diseases pose a major threat to viticulture worldwide, causing substantial yield losses and jeopardizing the long-term sustainability of vineyard systems.

The oomycete Plasmopara viticola (Berk. & M.A. Curtis) Berl. & De Toni, the causal agent of grapevine downy mildew, originated in the northeastern United States and was accidentally introduced into Europe in the mid-19th century.

Botrytis cinerea is a major fungal pathogen affecting viticulture, causing substantial economic losses due to reduced fruit quality and subsequent yield.

Over the past decades, lipids and fatty acids have emerged as pivotal regulators of plant–pathogen interactions.

For one of the major fungal diseases in cool-climate viticulture, Botrytis bunch rot (BBR), management practices as well as plant protection possibilities reach their limits.

As one of the most important crop plants in the world, securing grapevine yields and production quality is a top priority.

Achieving disease resistance in grapevine (Vitis vinifera) without compromising plant growth is a significant challenge for viticulture. Astrategy to reduce susceptibility to Downy Mildew (DM) is through dual inactivation of the salicylic acid (SA) hydroxylases VviDMR6-1 and VviDMR6-2 by gene editing, which leads to elevated endogenous SAlevels and enhanced immunity.

Grapevine is a globally significant crop whose productivity is constantly threatened by fungal and oomycete diseases.