Artificial intelligence (AI)-based protein modeling for the interpretation of grapevine genetic variants

More recently, studies have shown that polyphenols could also prevent or improve vision in patients with ocular diseases and especially age-related macular degeneration (AMD) which is an eye disease characterized by damage to the central part of the retina, the macula, and that affects millions of people worldwide. Despite therapeutic advances thanks to the use of anti-vascular endothelial growth factor (VEGF), many resistance mechanisms have been found to accentuate the visual deficit.

Plants have evolved different strategies to cope with environmental stresses and, although still debated, it was observed that they can remember past stress occurrence.
Anatomical and physiological adjustments have been observed in different grapevine cultivars after repeated drought exposure, however epigenetic, transcriptional and biochemical changes associated with drought-primed ecological memory have been poorly studied.
This work was conceived to test whether exposure to recurring events of mild drought could prime vines to endure severe drought stress. Particularly, we investigated whether the expected improved stress tolerance of Vitis vinifera cv Nebbiolo plants subjected over years to moderate and long-lasting water stress events (WS-primed) depended on molecular memory phenomena or on resetting of stress-induced signals.

Beyond the sole warming globally perceived and monitored, climate change impacts water availability. Increasing heatwaves frequency observed during the last decades

PR proteins can cause haze in wines, and the risk is to keep the wine unsold. Generally, in winemaking bentonite solves this problem by removing proteins, but it is not a renewable resource, has poor settling, which means difficulty in filtering after use and a considerable loss of wine, it is not a specific adsorbent and may reduce aromas and flavor compounds

In this last ten years period, there has been many integrated and interdisciplinary studies to determine the aptitude of different zones to viticulture (Lulli et al., 1989 ; Costantini, 1992 ; Fregoni et al., 1992). The researches needed some différent knowledges about environment characteristics (soil, climate), ecology, vineyard management, vine genetic, winemaking and sensory analysis. The interaction of all these knowledge produced the assessment about the environmental vocation (Scienza et al., 1992). By means of this metodology, the “viticultural vocation” joined the word “zoning”, that is the territory parting for its ecopedological and geographical characteristics in relation to adaptative answer of winegrape (Morlat, 1989).