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IVES 9 IVES Conference Series 9 Macrowine 9 Macrowine 2010 9 Berry development and biosynthesis of grape secondary metabolites 9 Investigation of VvDXS function and its effects on muscat flavor levels

Investigation of VvDXS function and its effects on muscat flavor levels


In the present study the connection between the positional candidate gene VvDXS and muscat flavor was evaluated by investigating the expression profiles in the berries from a Muscat-type cultivar and a neutral cultivar and its nucleotide diversity of full ORF on grapevine accessions. The relationship between the transcription profile of VvDXS alleles and monoterpenoid content suggests that a particular trend in gene expression rather than the level of expression ratio affects monoterpenoid accumulation in ‘‘Moscato Bianco’’. However a putative causal SNP responsible for a predicted non-neutral substitution was found to be significantly associated with muscat-flavored cultivars. Functional assays suggest that the putative causal SNP raises monoterpenoid accumulation by changing the 3D protein structure and by increasing VvDXS activity in Muscat enzyme form.

Publication date: July 3, 2024

Issue: Macrowine 2010

Type: Article


Juri BATTILANA1, Francesco EMANUELLI1, Laura COSTANTINI1, Giorgio GAMBINO2, Flavia GASPERI1, Ivana GRIBAUDO2, Patrice THIS3, Paul K. BOSS4, Maria Stella GRANDO1

1 IASMA Research and Innovation Centre, Fondazione Edmund Mach, Via Mach 1, 38010 San Michele all’Adige, TN, I. 

2 Istituto Virologia Vegetale – CNR Unità Grugliasco. Via Leonardo da Vinci 44, 10095 Grugliasco, TO, I.

3 INRA UMR 1097 DIAPC Diversité et Adaptation des Plantes Cultivées, Montpellier, F.

4 CSIRO Plant Industry Horticultural PO Box 350, Glen Osmond, SA 5064, AUS

Contact the author*


candidate gene, expression trend, association study, enzyme activity


IVES Conference Series | Macrowine | Macrowine 2010


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