The forchlorfenuron (CPPU) application is recommended in table-grape after fruit-set to boost berry sizing, albeit growers also apply CPPU during pre-flowering with controversial advantages. We examined the effect of single (BBCH 15) and double (BBCH 15 and 57) CPPU applications (2.25 mg/L a.s.) in a commercial vineyard. At each time, 75-100 bunches belonging to 6-9 vines were sprayed, and compared with unsprayed (CTRL). Leaf stomatal conductance (gs), cluster stem diameter and length were measured. At harvest, 25 berries/repetition were sampled for chemical composition, BSN incidence was counted (N° necrotic laterals/10 cm of stem) in 40 bunches/repetition. To test the role of air VPD on mineral composition, at BBCH 77, 50 CTRL clusters were bagged to induce a low VPD.