terclim by ICS banner
IVES 9 IVES Conference Series 9 International Congress on Grapevine and Wine Sciences 9 2ICGWS-2023 9 Molecularly imprinted polymers: an innovative strategy for harvesting polyphenoles from grape seed extracts

Molecularly imprinted polymers: an innovative strategy for harvesting polyphenoles from grape seed extracts

Abstract

Multiple sclerosis (MS) is a multifactorial autoimmune disease associating demyelination and axonal degeneration developing in young adults and affecting 2–3 million people worldwide. Plant polyphenols endowed with many therapeutic benefits associated with anti-inflammatory and antioxidant properties represent highly interesting new potential therapeutic strategies. We recently showed the safety and high efficiency of grape seed extract (GSE), a complex mixture of polyphenolics compounds comprising notably flavonoids and proanthocyanidins, in an experimental autoimmune encephalomyelitis (EAE) mouse model of MS.

We currently investigate molecularly imprinted polymers (MIPs) as a dedicated tool to efficiently extract polyphenols from GSE with high dosage, controlled composition and improved bioavailability. The materials will be tailored such that either a selection of already known and potent polyphenols will be extracted, or more generically, that the majority of GSE containing polyphenols will be extracted in a rather untargeted approach. The same MIPs based on biodegradeable polymers will be used as innovative pharmaceutical formulations / drug delivery matrices packaging the polyphenols extracted from grape by-products, which serve as a resource of bioactive compounds with the distinct circular economic effect of reducing winemaking environmental impact.

Acknowledgements: We would like to thank the International Ambition Pack from La Région Auvergne-Rhône-Alpes for support of this project.

1)  A. Molinelli et al., Advanced Solid Phase Extraction Using Molecularly Imprinted Polymers for the Determination of Quercetin in Red Wine, Journal of Agricultural and Food Chemistry, 50 (7), 1804–1808 (2002), DOI: 10.1021/jf011213q

2)  S. Rajpal et al., An in silico predictive method to select multimonomer combinations for peptide imprinting, J. Mater. Chem. B 10, 6618-6626 (2022), DOI: https://doi.org/10.1039/D2TB00418F

3)  A. Kotyrba et al., Development of Silica Nanoparticle Supported Imprinted Polymers for Selective Lysozyme Recognition, Nanomaterials 11(12), 3287 (2021), DOI: https://doi.org/10.3390/nano11123287

DOI:

Publication date: October 5, 2023

Issue: ICGWS 2023

Type: Article

Authors

Boris Mizaikoff1,2*, Anika Kotyrba1, Mélina Begou2

1Ulm University, Institute of Analytical and Bioanalytical Chemistry, Ulm, Germany
2Hahn-Schickard, Ulm, Germany
3Université Clermont Auvergne, Department of Pharmacology, Clermont, France

Contact the author*

Keywords

molecularly imprinted polymers, polyphenols, grape seed extract, multiple sclerosis

Tags

2ICGWS | ICGWS | ICGWS 2023 | IVES Conference Series

Citation

Related articles…

Atypical aging and hydric stress: insights on an exceptionally dry year

Atypical aging (ATA) is a white wine fault characterized by the appearance of notes of wet rag, acacia blossoms and naphthalene, along with the vanishing of varietal aromas. 2-aminoacetophenone (AAP) – a degradation compound of indole-3-acetic acid (IAA) – is regarded as the main sensorial and chemical marker responsible for this defect. About the origin of ATA, a stress reaction occurring in the vineyard has been looked as the leading cause of this defect. Agronomic, climatic and pedological factors are the main triggers and among them, drought stress seems to play a crucial role.[1]

Applicability of spectrofluorometry and voltammetry in combination with machine learning approaches for authentication of DOCa Rioja Tempranillo wines

The main objective of the work was to develop a simple, robust and selective analytical tool that allows predicting the authenticity of Tempranillo wines from DOCa Rioja. The techniques of voltammetry and absorbance-transmission and fluorescence excitation emission matrix (A-TEEM) spectroscopy have been applied in combination with machine learning (ML) algorithms to classify red wines from DOCa Rioja according to region (Alavesa, Alta or Oriental) and category (young, crianza or reserva).

Wine odors: chemicals, physicochemical and perceptive processes involved in their perception

The odors of wines are diverse, complex and dynamic and much research has been devoted to the understanding of their chemical bases. However, while the “basic” chemical part of the problem, namely the identity of the chemicals responsible for the different odor nuances, was satisfactorily solved years ago, there are some relevant questions precluding a clear understanding. These questions are related to the physicochemical interactions determining the effective volatilities of the odorants and, particularly, to the perceptual interactions between different odor molecules affecting in different ways to the final sensory outputs.

Foliar application of urea improved the nitrogen composition of Chenin grapes

The nitrogen composition of the grapes directly affects the developments of alcoholic fermentation and influences the final aromatic composition of the wines. The aim of this study was to determine the effect and efficiency of foliar applications of urea on the nitrogen composition of grapes. This study was carried out during 2023 vintage and in the Chenin vineyard located in Estacion Experimental Mendoza (Argentina). Three urea concentrations 3, 6 and 9 Kg N/ha (C1, C2, and C3, respectively) and control (T) were applied in this vineyard at veraison. In all solutions were added 1ml/l of Tween 80 ® surfactant.

Late pruning, an alternative for rainfed vine varieties facing new climatic conditions

In Chile there is a dry farming area known as a traditional wine region, where varieties brought by the Spanish conquerors still persist. These varieties, in general, are cultivated under traditional systems, with low use of technical and economic resources, and low profitability for their grapes and wines. In this region, as in other wine grape growing areas, climatic conditions have changed significantly in recent decades. In particular, the occurrence of spring frosts, when bud break has already begun, have generated significant losses for these growers.